INSERTECH

         Main publications of the INSERM U898 (Nice, France)

 Projects 1 & 2: Pluripotent stem cells, p63 and epithelial differentiation

(Leader: D. Aberdam)

Coraux et al. (2003) Reconstituted skin from murine ES cells Curr Biol. 13, 849-853. pdf

Ferrigno et al (2001) Transposable B2 SINE elements can provide mobile RNA pol II promoters. Nat genetics 28, 77-81 pdf

US Patent on keratinocytes from ES cells. pdf 

Aberdam D. (2004) Derivation of keratinocyte progenitor cells and skin formation from ES cells. Int J Dev. Biol. 48, pdf

Barthel and Aberdam. (2005) Epidermal stem cells. JEADV. 19,1-9 pdf

Aberdam et al. (2005) Embryonic stem cells and epidermal commitment. Bull Acad Natl Med.189:645-52; discussion 652-3. pdf

Gambaro et al. (2006) BMP-4 induces a smad-dependent apoptotic cell death of mouse ES cell-derived neural precursors. Cell Death Diff. 13, 1075-87 pdf

Aberdam D. et al. (2007) Key role of p63 in BMP-4-induced epidermal commitment of embryonic stem cells. Cell cycle 6, 291-4  pdf

Aberdam D. et al. (2007) ES cells as a cellular model for neuroectodermal commitment and skin formation. C.R. Biol. 330(6-7):479-84.  pdf

 
Aberdam D. (2008) Epidermal stem cell fate: what can we learn from embryonic stem cells?
Cell Tissue Res. 331, 103-107  pdf

 

Aberdam E. et al. (2008) A pure ectodermal cell population derived from human ES cells. Stem cells, 26:440-444. pdf

Aberdam E and Aberdam D. (2008) Embryonic stem cells and skin: from cellular model to therapeutic potential. J. Soc Biol. 202, 15-23  pdf

Aberdam D et al. (2008) miR, "stemness" and skin. trends Biochem. Sci, Oct 8. [Epub ahead of print]. pdf

Lena AM, Shalom-Feuerstein R et al. (2008) miR-2003 represses "stemness" by repressing DNp63. Cell Death Diff., 15,1187-95. pdf

Medawar et al. (2008) DNp63 is essential for epidermal commitment of embryonic stem cells. PLoS ONE 3(10): e3441. pdf

Hewitt KJ, Shamis Y, Carlson MW, Aberdam E, Aberdam D, Garlick J. Three-dimensional epithelial tissues generated from human embryonic stem cells. Tissue Eng Part A. 2009 Apr 30. [Epub ahead of print]. pdf

Aberdam D, Mantovani R. A new p63-deficient mouse model or a fresh look at an old one? Cell Death Differ. 2009 Aug;16(8):1073-4. pdf

 Project 3: cancer stem cells: genotoxic stress, self renewal and plasticity (Leader: T. Virolle)

 

Virolle et al (2000) DNA conformation triggers cell specific expression. Embo R. 11, 328-333 pdf

 

Virolle et al. (2001) The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol. 3:1124-8. pdf

Virolle et al. (2003) Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes. J Biol Chem. 278:11802-10. pdf

Thyss et al. (2006) NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J. 24:128-37 pdf

Chassot et al. (2007) Id3 is a novel regulator of p27(kip1) mRNA in early G1 phase and is required for cell-cycle progression. Oncogene. Apr 2;
pdf

Turchi et al. (2008) Hif-2alpha mediates UV induced apoptosis through a novel ATF3 dependent death pathway. Cell Death Diff. 15,1472-80.   pdf

Turchi et al. (2009) ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress. Cell Death Diff. 16(5):728-37. pdf